Blood Coagulation in Liver Diseases

Role of blood coagulation factor XIII in vascular diseases.

FXIII, also called fibrin-stabilising factor [1] , is a transglutaminase composed of two A subunits and two B subunits circulating in plasma as a tetramer (A2B2) (Figure 1). FXIII plays an important role in clot stabilisation by cross-linking fibrin chains [2] after activation by thrombin (Figure 1). In addition, a number of other proteins are substrates for activated FXIII, such as α2-antiplas...

Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases

Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). The protease-activated receptors (PARs) pathway can be considered the central hub of this regulatory network, mainly through thrombin or activated protein C (aPC). These proteins, in fact, showed pecul...

Coagulation in Liver Disease

Changes in blood coagulation.

Studies in Blood Coagulation

Description is given of changes in blood coagulability found in diseases of the rabbit, including malignant tumor, spontaneous infections, non-bacterial diseases and lesions, and hemorrhagic states specifically induced. The changes involved variously the time of onset of blood coagulation, clot formation rate and the rate and extent of clot retraction.